Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

Background Obstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum plasma) cortisol concentrations of individuals OSAS to those healthy controls. Methods made a systematic search without any restrictions the PubMed/Medline, Scopus, Cochrane Library, Web Science databases for relevant articles published up August 25, 2019. Results Sixteen studies were analyzed this meta-analysis; five compared concentrations, serum four plasma two both concentrations. In pediatric samples, controls, had significantly lower saliva (MD = -0.13 µg/dl; 95% CI: 0.21, -0.04; P 0.003). contrast, no significant differences observed or between adults ( p 0.61, 0.17, 0.17). Conclusion Cortisol did not differ children OSAS, Given that reduced HPA AA is among chronic stress, it conceivable are experiencing psychophysiological stress.